Job summaryNorth Thames Genomics Laboratory Hub- Band 8a Senior Clinical ScientistThe Rare Disease Laboratory has an establishment of approximately 180 including technologists, Clinical Scientists, translational scientists, bioinformaticians and administrative support staff. Along with two Clinical Genetics teams we form a strategic Genetics Unit withinthe hospital and provide North London with a Regional Genetics Service serving a population of approximately 10 million.Having been awarded 11 specialisms in the NHSE Genomic Medicine Service, the rare disease laboratory provides an in-house diagnostic service for molecular and cytogenetic testing in accordance with the NHS England Genomic Test Directory. Testing is provided for both prenatal and postnatal samples using Next generation sequencing, SNP microarray, karyotyping, FISH, MLPA, qPCR, ddPCR, NIPD and other targeted tests. We are also engaged in the delivery of the NHSE GMS Whole Genome Sequencing programme for our North Thames patients and specialist WGS for larger areas of England.We are involved in a number of collaborative research and development projects with colleagues at the UCL Institute of Child Health and Institute of Neurology as part of the UCL Partners Academic Health Sciences Centre.Informal enquiries can be made to Sam Loughlin Email: Sam.Loughlin@gosh.nhs.ukMain duties of the job The Rare Disease Genomics Laboratory at Great Ormond Street Hospital is inviting applications from experienced HCPC registered Clinical Scientists in Genomics to join an expanding team delivering rare disease genomic tests for the North Thames Genomic Laboratory Hub.Experience in analysis, interpretation and reporting of genomic tests (molecular genetic and/or cytogenetic) is essential. Experience of authorising genomic reports and Part 1 FRCPath are desirable.As Senior Clinical Scientists, the postholders would be responsible for the day-to-day running of a designated area of the rare and inherited disease genomics service, including supervision of clinical scientists, for the delivery of a reliable, competitive, efficient, cost effective and high quality clinical diagnostic service. An additional interest in Workforce training, Automation/Innovation, or Quality (ISO15189:2022) would be an advantage.We support trained scientists who wish to adopt flexible and/or hybrid working patterns. For Clinical Scientists, after a successful probation period, there is a requirement to work on-site for 40% of working hours.About us GOSH is committed to recruiting the best person for the job, based solely on their ability and individual merit as measured against the criteria for the role; through a process that is fair, open, consistent and free from bias and discrimination.We are committed to being a diverse and inclusive employer and foster a culture where all staff are valued, respected and acknowledged. All applicants will receive consideration for employment without regard to race, colour, national origin, religion, sexual orientation, gender, gender identity, age, disability status or length of time spent unemployed.We particularly welcome applications from BAME communities, people with disabilities and/or long-term health conditions and LGBT+ community members.We have policies and procedures in place to ensure that all applicants and employees are treated fairly and consistently. We are proud to be accredited as a Disability Confident Employer, a member of Business Disability Forum and a Stonewall Diversity Champion.We have active and Executive supported BAME, LGBT+ and Allies, Disability and Long-Term Health Conditions and Women''s staff networks. Staff networks are employee-led groups formed around interests, issues and a common bond or background. Staff network members create a positive and inclusive work environment at Great Ormond Street Hospital by actively contributing to the Trust''s mission, values and efforts specific to inclusion. All of our staff networks are open to any employee.Details Date posted 22 August 2025Pay scheme Agenda for changeBand Band 8aSalary £64,156 to £71,148 a year per annum inclusiveContract PermanentWorking pattern Full-timeReference number 271-GEN-7411040Job locations Great Ormond Street Hospital for Children NHS Foundation TrustGreat Ormond Street HospitalLondonWC1N 3JH

Job description Job responsibilities The full job description provides an overview of the key tasks and responsibilities of the role, and the person specification outlines the qualifications, skills, experience and knowledge required. For both documents please view the attachment/s below.Job description Job responsibilities The full job description provides an overview of the key tasks and responsibilities of the role, and the person specification outlines the qualifications, skills, experience and knowledge required. For both documents please view the attachment/s below.Person Specification GOSH Culture and Values Essential

Our Always valuesAcademic/Professional qualification/Training Essential

1st or 2nd class honours degree in a relevant biological subjectState Registered Clinical Scientist (HCPC)Commitment to RCPath FellowshipRCPath Part 1Desirable

Higher degree or externally assessed equivalent level of knowledge and expertise within the speciality of Genetics/GenomicsRoyal College of Pathologists Fellowship (FRCPath)Experience/Knowledge Essential

Post-registration experience in a regional clinical genomics rare and inherited disease serviceExtensive and comprehensive knowledge of genomic diagnostic methods required in a regional clinical genomics rare and inherited disease serviceUp to date knowledge of scientific literature and best practice guidance relating to molecular genetic and cytogenetic testsKnowledge of appropriate Quality Management and Audit regulations and requirementsEvidence of an active programme of continuing professional developmentDesirable

To have completed a formal postgraduate training programme approved as appropriate for registration together with in service experienceExperience of molecular cytogenetics techniques and their application within a regional clinical cytogenetics serviceExperience of participation in external quality assessment schemes for genomic testsExperience of training pre-registration scientistsKnowledge of appropriate Health and Safety regulations and requirementsSkills/Abilities Essential

Positive, "can do" attitude to workEvidence of good inter-personal communication skillsSkilled in the microscopic diagnosis of chromosome abnormalitySkilled in the interpretation and reporting of complex genomic results, including giving advice on the implications and reproductive risks for patients and familiesAble to critically analyse and interpret scientific dataVerbal and written presentation and communication skills. Able to present data at departmental and inter-departmental meetings.Ability to write and authorize normal, abnormal and complex reportsComputer literate including use of Genetic databases and analytical softwarePerson Specification GOSH Culture and Values Essential

Our Always valuesAcademic/Professional qualification/Training Essential

1st or 2nd class honours degree in a relevant biological subjectState Registered Clinical Scientist (HCPC)Commitment to RCPath FellowshipRCPath Part 1Desirable

Higher degree or externally assessed equivalent level of knowledge and expertise within the speciality of Genetics/GenomicsRoyal College of Pathologists Fellowship (FRCPath)Experience/Knowledge Essential

Post-registration experience in a regional clinical genomics rare and inherited disease serviceExtensive and comprehensive knowledge of genomic diagnostic methods required in a regional clinical genomics rare and inherited disease serviceUp to date knowledge of scientific literature and best practice guidance relating to molecular genetic and cytogenetic testsKnowledge of appropriate Quality Management and Audit regulations and requirementsEvidence of an active programme of continuing professional developmentDesirable

To have completed a formal postgraduate training programme approved as appropriate for registration together with in service experienceExperience of molecular cytogenetics techniques and their application within a regional clinical cytogenetics serviceExperience of participation in external quality assessment schemes for genomic testsExperience of training pre-registration scientistsKnowledge of appropriate Health and Safety regulations and requirementsSkills/Abilities Essential

Positive, "can do" attitude to workEvidence of good inter-personal communication skillsSkilled in the microscopic diagnosis of chromosome abnormalitySkilled in the interpretation and reporting of complex genomic results, including giving advice on the implications and reproductive risks for patients and familiesAble to critically analyse and interpret scientific dataVerbal and written presentation and communication skills. Able to present data at departmental and inter-departmental meetings.Ability to write and authorize normal, abnormal and complex reportsComputer literate including use of Genetic databases and analytical softwareDisclosure and Barring Service Check This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.Certificate of Sponsorship Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the

UK Visas and Immigration website (Opens in a new tab) .From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement.

Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab) .UK Registration Applicants must have current UK professional registration. For further information please see

NHS Careers website (opens in a new window).Additional information Disclosure and Barring Service Check This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.Certificate of Sponsorship Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the

UK Visas and Immigration website (Opens in a new tab) .From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement.

Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab) .UK Registration Applicants must have current UK professional registration. For further information please see

NHS Careers website (opens in a new window).Employer details Employer name Great Ormond Street Hospital for Children NHS Foundation TrustAddress Great Ormond Street Hospital for Children NHS Foundation TrustGreat Ormond Street HospitalLondonWC1N 3JH

Employer''s website

https://www.gosh.nhs.uk/ (Opens in a new tab)Employer details Employer name Great Ormond Street Hospital for Children NHS Foundation TrustAddress Great Ormond Street Hospital for Children NHS Foundation TrustGreat Ormond Street HospitalLondonWC1N 3JH

Employer''s website

https://www.gosh.nhs.uk/ (Opens in a new tab)

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